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    Generic Name: Azithromycin (multiple manufacturers) Common Brand Name: Zithromax (Pfizer — U. S.) Popularity: 11th most commonly prescribed drug between 2002 — 2007 (U. S.) Class: Macrolide antibiotic Treatment Uses — For treatment of bacterial infections. Azithromycin has distinct advantages over earlier macrolides such as erythromycin that include better tolerance, better tissue penetration and more favorable pharmacokinetics. Because azithromycin can be dosed once daily, it improves patient compliance — a leading cause of antibiotic failures. Macrolides act primarily against streptococci and staphylococci, and are often used to treat these bugs in patients intolerant of penicillins. The therapeutic uses for azithromycin are broad and continually changing. [Posted 08/03/2018]AUDIENCE: Patient, Health Professional, Oncology ISSUE: The antibiotic azithromycin (Zithromax, Zmax) should not be given long-term to prevent a certain inflammatory lung condition in patients with cancers of the blood or lymph nodes who undergo a donor stem cell transplant. Results of a clinical trial found an increased rate of relapse in cancers affecting the blood and lymph nodes, including death, in these patients. We are reviewing additional data and will communicate our conclusions and recommendations when our review is complete. BACKGROUND: The serious lung condition for which long-term azithromycin was being studied called bronchiolitis obliterans syndrome is caused by inflammation and scarring in the airways of the lungs, resulting in severe shortness of breath and dry cough. Cancer patients who undergo stem cell transplants from donors are at risk for bronchiolitis obliterans syndrome. The manufacturer of brand name azithromycin is providing a Dear Healthcare Provider letter on this safety issue to health care professionals who care for patients undergoing donor stem cell transplants. Azithromycin is not approved for preventing bronchiolitis obliterans syndrome.

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    If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects can include: If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room. Don’t take this drug again if you’ve ever had an allergic reaction to it. Disclaimer: Our goal is to provide you with the most relevant and current information. HOW TO USE THIS MEDICINE: It is preferable to take this medicine with food to avoid stomach upset. Do not take antacids such as Maalox within two hours of taking this medication. If you vomit within 1 hour after taking medication, you will need to be re-treated. SIDE EFFECTS: You may get nausea, stomach pain, vaginal irritation or rash. If these side effects do not go away or get worse, or if you notice other side effects not listed above, check with your doctor. Do not have sex for seven days after taking this medication. Tell your sex partner(s) to be tested and/or treated, whether they have symptoms or not. If you have unprotected sex with your partner and they have not been treated, you can get this infection again. If you have more questions about chlamydia or other sexually transmitted infections visit our website at org and or contact your health care provider.

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